Sex hormones

Adv Mater. 2016 Aug;28(30):6345-52. doi: 10.1002/adma.201600554. Epub 2016 May 11.
Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer’s Disease Therapy.
Zhang R1,2, Li Y1, Hu B1, Lu Z1,3, Zhang J2, Zhang X1.
Author information
Abstract
Nanoparticles that can efficiently control the differentiation of neural stem cells (NSCs) into neurons are developed for Alzheimer’s disease (AD) therapy. The treatment with these nanoparticles results in an attenuation of neuronal loss and rescues memory deficiencies in mice. The system can also be used to monitor the transplantation site, as well as the migration of NSCs in real time. Therefore, the system is proposed to open up new avenues for AD treatment.
© 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
KEYWORDS:
Alzheimer’s disease; RNA; interference; magnetic resonance imaging; nanoparticles; neural stem cells
PMID: 27168033 DOI: 10.1002/adma.201600554

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